Coats’ disease, also known as Exudative Retinitis or exudative retinopathy.
It is a progressive condition of the retinal capillaries which occurs in
children and young adults, usually males. Commencing typically during the first
decade of life, it is gradual in progress and affects central vision, usually in
only one eye.
Retinal capillaries play an important part in the nourishment of the retina
which forms the thin light-sensitive screen lining the inside of the back two
thirds of the eye. Light reaching the retina is converted into electrical
impulses which pass along the optic nerve to the brain where the impulses are
converted to sight.
Also known as:
Exudative retinitis, exudative retinopathy, retinitis circinata, retinitis
exudativa, retinitis exudativa externa, retinitis haemorrhagica externa, retinal
Mutations in the
Norrie Disease (ND)
gene are associated with a spectrum of retinal findings
ranging from Norrie disease (ND) to X-linked familial exudative
vitreoretinopathy (FEVR), including some cases of persistent hyperplastic
primary vitreous (PHPV), Coats disease, and advanced retinopathy of prematurity
(ROP). Rarely, carrier females can evidence a clinical phenotype. These
phenotypes appear to be a continuum of retinal findings with considerable
overlap (Table 1
). The ocular findings that
permit a presumptive diagnosis of an ND-spectrum disorder include the following:
MORE ON MUTATION OF
NORRIE DISEASE CAUSING COATS
LINKS FOR MORE INFORMATION
Coats’ Disease (also known as
Exudative Retinitis) factsheet
Coats Disease – Article
disease by Doctor Alessandra Del Longo
- G. Coats:
Forms of retinal disease with massive exudation.
Royal London Ophthalmic Hospital Reports, 1908, 17, 3: 440-525.