Information on the inheritance of FEVR.
Autosomal dominant (AD) is the most common form of inheritance of FEVR. The frizzled-4 gene was recently discovered in 11q chromosome as one of the genes that cause AD FEVR. Another locus for AD disease is in 11p, this the gene is still unknown. It is quite possible that few other unknown yet genes might cause AD FEVR.The second most common form of tranmsmission is x-linked. Patients with the x-linked form have quite often mutations in the Norrie disease gene. It is quite possible also that this type of FEVR could also be caused by other genes as well. A third type of inheritance is autosomal recessive, it is the least common and genes are still unknown.
|: Clin Genet 1998 Oct;54(4):315-20||Related Articles, Links|
|Am J Med Genet 1997 Mar 17;69(2):217-8||Related Articles, Links|